Chemistry and cellular aspects of cationic facial amphiphiles
Identifieur interne : 002772 ( Main/Exploration ); précédent : 002771; suivant : 002773Chemistry and cellular aspects of cationic facial amphiphiles
Auteurs : Suzanne Walker [États-Unis] ; Michael J. Sofia [États-Unis] ; Helena R. Axelrod [États-Unis]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 1998.
English descriptors
- Teeft :
- Acid, Active ester, Amine, Amphiphiles, Amphiphilic, Best compound, Best compounds, Bile, Bile acid, Bile acid core, Bile acid derivatives, Bile acid skeletons form, Bone marrow, Breast carcinoma, Breast carcinoma monkey kidney, Broblasts, Carcinoma, Cationic, Cationic delivery agents, Cationic lipids, Cell lines, Cell membranes, Charge ratio, Chem, Chenodeoxycholic acid, Chloramphenicol acetyltransferase, Chloroquine, Cholic, Cholic acid, Complex stability, Compound, Confocal microscopy experiments, Cultured cells, Delivery agents, Delivery formulations, Delivery reagents, Deoxycholic acid, Derivative, Dope, Drug delivery reviews, Endosome, Enzyme activity, Facial, Facial amphiphile, Facial amphiphiles, Facial amphiphilicity, Facially, Further improvements, Gene, Gene delivery, Gene delivery agents, Gene expression, Gene therapy, Gene transfer, Good transfection activity, Hcmv promoter, Hexamine side chain, High activity, High transfection activity, Hydrophobic, Hydrophobic interactions, Hydroxyl, Initial experiments, Lipid, Lipofectin, Lithocholic acid, Luciferase gene expression, Membrane fusion, Monkey kidney, Murine mucopolysaccharidosis type, Nude mice, Oligonucleotide delivery, Optimal concentration, Optimal molar ratio, Pentaethylenehexamine, Pentamine conjugate, Peptide, Personal communication, Plasma membrane, Plasmid, Polyamine, Positive charges, Primary skin, Princeton university, Protonatable amines, Reporter genes, Room temperature, Side chain, Spermine, Stable complexes, Steroidal, Steroidal polyamines, Transfection, Transfection activity, Transfection agents, Uorescent oligonucleotides, Viral vectors.
Abstract
Abstract: A series of compounds containing a bile acid core and a polyamine side chain have been synthesized to evaluate their ability to promote the uptake of DNA into cells. These compounds differ from conventional cationic lipids because they contain a positively charged chain attached to a facial amphiphile rather than to a hydrophobic moiety. Formulations of several of the designed compounds were found to dramatically increase the cellular uptake of both plasmid and oligonucleotide DNA. Moreover, initial experiments have shown that some of the compounds promote plasmid gene expression in various tissues after introduction into animals. These results have provided interesting information about structure–activity relationships as well as clues to the mechanism of action that may lead to further improvements in the design.
Url:
DOI: 10.1016/S0169-409X(97)00107-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D37
- to stream Istex, to step Curation: 000D37
- to stream Istex, to step Checkpoint: 001576
- to stream Main, to step Merge: 002814
- to stream Main, to step Curation: 002772
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Chemistry and cellular aspects of cationic facial amphiphiles</title><author><name sortKey="Walker, Suzanne" sort="Walker, Suzanne" uniqKey="Walker S" first="Suzanne" last="Walker">Suzanne Walker</name></author><author><name sortKey="Sofia, Michael J" sort="Sofia, Michael J" uniqKey="Sofia M" first="Michael J" last="Sofia">Michael J. Sofia</name></author><author><name sortKey="Axelrod, Helena R" sort="Axelrod, Helena R" uniqKey="Axelrod H" first="Helena R" last="Axelrod">Helena R. Axelrod</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FFAEDD54A157077479231BF1D4D9DB979543596A</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0169-409X(97)00107-5</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-SSFC248C-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000D37</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D37</idno><idno type="wicri:Area/Istex/Curation">000D37</idno><idno type="wicri:Area/Istex/Checkpoint">001576</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001576</idno><idno type="wicri:doubleKey">0169-409X:1998:Walker S:chemistry:and:cellular</idno><idno type="wicri:Area/Main/Merge">002814</idno><idno type="wicri:Area/Main/Curation">002772</idno><idno type="wicri:Area/Main/Exploration">002772</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Chemistry and cellular aspects of cationic facial amphiphiles</title><author><name sortKey="Walker, Suzanne" sort="Walker, Suzanne" uniqKey="Walker S" first="Suzanne" last="Walker">Suzanne Walker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Chemistry, Princeton University, Princeton</wicri:cityArea></affiliation></author><author><name sortKey="Sofia, Michael J" sort="Sofia, Michael J" uniqKey="Sofia M" first="Michael J" last="Sofia">Michael J. Sofia</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Transcell Technologies Inc., 8 Cedar Brook Drive, Cranbury</wicri:cityArea></affiliation></author><author><name sortKey="Axelrod, Helena R" sort="Axelrod, Helena R" uniqKey="Axelrod H" first="Helena R" last="Axelrod">Helena R. Axelrod</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Transcell Technologies Inc., 8 Cedar Brook Drive, Cranbury</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Advanced Drug Delivery Reviews</title><title level="j" type="abbrev">ADR</title><idno type="ISSN">0169-409X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">1–3</biblScope><biblScope unit="page" from="61">61</biblScope><biblScope unit="page" to="71">71</biblScope></imprint><idno type="ISSN">0169-409X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-409X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid</term><term>Active ester</term><term>Amine</term><term>Amphiphiles</term><term>Amphiphilic</term><term>Best compound</term><term>Best compounds</term><term>Bile</term><term>Bile acid</term><term>Bile acid core</term><term>Bile acid derivatives</term><term>Bile acid skeletons form</term><term>Bone marrow</term><term>Breast carcinoma</term><term>Breast carcinoma monkey kidney</term><term>Broblasts</term><term>Carcinoma</term><term>Cationic</term><term>Cationic delivery agents</term><term>Cationic lipids</term><term>Cell lines</term><term>Cell membranes</term><term>Charge ratio</term><term>Chem</term><term>Chenodeoxycholic acid</term><term>Chloramphenicol acetyltransferase</term><term>Chloroquine</term><term>Cholic</term><term>Cholic acid</term><term>Complex stability</term><term>Compound</term><term>Confocal microscopy experiments</term><term>Cultured cells</term><term>Delivery agents</term><term>Delivery formulations</term><term>Delivery reagents</term><term>Deoxycholic acid</term><term>Derivative</term><term>Dope</term><term>Drug delivery reviews</term><term>Endosome</term><term>Enzyme activity</term><term>Facial</term><term>Facial amphiphile</term><term>Facial amphiphiles</term><term>Facial amphiphilicity</term><term>Facially</term><term>Further improvements</term><term>Gene</term><term>Gene delivery</term><term>Gene delivery agents</term><term>Gene expression</term><term>Gene therapy</term><term>Gene transfer</term><term>Good transfection activity</term><term>Hcmv promoter</term><term>Hexamine side chain</term><term>High activity</term><term>High transfection activity</term><term>Hydrophobic</term><term>Hydrophobic interactions</term><term>Hydroxyl</term><term>Initial experiments</term><term>Lipid</term><term>Lipofectin</term><term>Lithocholic acid</term><term>Luciferase gene expression</term><term>Membrane fusion</term><term>Monkey kidney</term><term>Murine mucopolysaccharidosis type</term><term>Nude mice</term><term>Oligonucleotide delivery</term><term>Optimal concentration</term><term>Optimal molar ratio</term><term>Pentaethylenehexamine</term><term>Pentamine conjugate</term><term>Peptide</term><term>Personal communication</term><term>Plasma membrane</term><term>Plasmid</term><term>Polyamine</term><term>Positive charges</term><term>Primary skin</term><term>Princeton university</term><term>Protonatable amines</term><term>Reporter genes</term><term>Room temperature</term><term>Side chain</term><term>Spermine</term><term>Stable complexes</term><term>Steroidal</term><term>Steroidal polyamines</term><term>Transfection</term><term>Transfection activity</term><term>Transfection agents</term><term>Uorescent oligonucleotides</term><term>Viral vectors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A series of compounds containing a bile acid core and a polyamine side chain have been synthesized to evaluate their ability to promote the uptake of DNA into cells. These compounds differ from conventional cationic lipids because they contain a positively charged chain attached to a facial amphiphile rather than to a hydrophobic moiety. Formulations of several of the designed compounds were found to dramatically increase the cellular uptake of both plasmid and oligonucleotide DNA. Moreover, initial experiments have shown that some of the compounds promote plasmid gene expression in various tissues after introduction into animals. These results have provided interesting information about structure–activity relationships as well as clues to the mechanism of action that may lead to further improvements in the design.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Walker, Suzanne" sort="Walker, Suzanne" uniqKey="Walker S" first="Suzanne" last="Walker">Suzanne Walker</name></region><name sortKey="Axelrod, Helena R" sort="Axelrod, Helena R" uniqKey="Axelrod H" first="Helena R" last="Axelrod">Helena R. Axelrod</name><name sortKey="Sofia, Michael J" sort="Sofia, Michael J" uniqKey="Sofia M" first="Michael J" last="Sofia">Michael J. Sofia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002772 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002772 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:FFAEDD54A157077479231BF1D4D9DB979543596A
|texte= Chemistry and cellular aspects of cationic facial amphiphiles
}}
| This area was generated with Dilib version V0.6.33. |  |